OBJECTIVES 1. Describe the synthesis of the study hormones that regulate metabolism. A. Insulin B. Glucagon C. Glucocorticoids D. Epinephrine/Norepinephrine 2. trade the signaling transduction of the hormones. sensory receptor mansion cascade 3. Explain the biochemical cause of the hormones on metabolism. A. Carbohydrate B. Lipid C. Protein 4. Explain the biochemical abnormalities associated with hormones that regulate metabolism. Hypersecretion Hyposecretion SYNTHESIS OF INSULIN (Remember: radical 1 steroid hormones theme 2 peptide hormones Group 3 - peptide hormones that wear steroid akin properties) *insulin is in group 2, so its sensory receptor is in the plasma membrane, and it is synthesized as a large whit consequently undergoes modification. [pic] 1. Preproinsulin: MW = 11,500 ? Pre or Leader era: 23 hydrophobic aminic acids; function is to guide preproinsulin to trip out to the ER. Once in the ER, the attracter sequence is then cleaved to assortment proinsulin. ? components: leader sequence, A and B grasps and C peptide mountain chain 2. Proinsulin: MW = 9000 ? Sequence: B chain C peptide A chain ? C peptide dictates where disulfide fond regards should be located.
MATURE INSULIN ? A nice protein (MW: 5700) that consists of two chains, A and B linked by disulfide bridge from cysteine residues ? A chain: 21 amino acids, B chain: 30 AAs = 51 AAs ? 2 Inter-chain S-S bridges that marry A & B chains: A7 to B7, and A20 to B19 ? A 3rd intrachain disulfide bond connects residues A6 to A11 ? Does non exist as suppurate insulin alone, it is precipitated with zinc Receptor enzyme: Receptor Tyrosine kinase * able to phosphorylate critical tyrosine residues which are set in motion in the B subunit *2 extra-cellular ? sub-units that contain the Insulin binding domains *2 transmembrane ? sub-units that contain the Protein...If you motive to feature a full essay, roam it on our website: Ordercustompaper.com
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